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Updated: May 1, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

Transdermal Minimally Invasive Optical Multiplex Detection of Protein Biomarkers by Nanopillars Array-Embedded

Adva Raz¹, Hila Gubi², Adam Cohen¹

¹Department of Materials Science and Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv 69978, Israel.

|October 28, 2024

Summary

This summary is machine-generated.

This study introduces a novel microneedle biosensor for rapid, minimally invasive detection of biomarkers in capillary blood. This blood extraction-free platform offers high sensitivity and specificity for early disease diagnosis.

Keywords:

biomarkers detection bloodless minimally invasive nanopillars array transdermal

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Area of Science:

Biomedical Engineering
Nanotechnology
Diagnostics

Background:

Current biomarker detection relies on invasive venous blood draws, which are time-consuming and complex.
Minimally invasive biosensors using microneedles for capillary blood analysis are gaining interest for point-of-care diagnostics.

Purpose of the Study:

To develop a novel microneedle-based biosensor for direct optical detection and quantification of biomarkers in capillary blood.
To demonstrate a fabrication method for multiplex intradermal biomarker detection without blood extraction.

Main Methods:

Fabrication of microneedles embedded with vertically aligned silicon nanopillar arrays.
Area-selective chemical modification of nanopillar arrays for antibody-antigen binding.
Direct optical detection of protein biomarkers in capillary blood via antibody-antigen interactions.

Main Results:

Successful fabrication of a multidetection-zone silicon nanopillar array in microneedle elements.
Demonstrated simultaneous, ultrafast, and highly sensitive detection of protein biomarkers.
Achieved low picomolar (pM) sensitivity and high specificity in preliminary in vitro and in vivo studies.

Conclusions:

The developed intradermal biosensor platform enables blood extraction-free, in-skin sampling and detection of biomarkers.
This technology offers a promising approach for sensitive, specific, and rapid point-of-care diagnostics.
The platform facilitates multiplex detection of clinically relevant protein biomarkers with excellent performance.