Asymmetric cyclopropanation via an electro-organocatalytic cascade
Anastasiya Krech1, Marharyta Laktsevich-Iskryk1, Nora Deil1
1Department of Chemistry and Biotechnology, Tallinn University of Technology, Akadeemia tee 15, Tallinn 12618, Estonia. maksim.oseka@taltech.ee.
Abstract:
We report an iminium ion-promoted, asymmetric synthesis of cyclopropanes via an electrocatalytic, iodine-mediated ring closure. The mild, controlled electrochemical generation of electrophilic iodine species in catalytic quantities prevents organocatalyst deactivation, while also eliminating the need for halogenating reagents, thus simplifying traditional synthetic approaches.
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