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Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
Published on: March 14, 2017
Tertiary Hyperparathyroidism: A Case Report
Carolina Fernandes1, Vera Vieira2, Cláudia Diogo1
1Internal Medicine Department, Unidade Local de Saúde da Região de Leiria, Leiria, PRT.
Abstract:
Tertiary hyperparathyroidism is characterized by increased parathyroid hormone (PTH) secretion that appears after prolonged secondary hyperparathyroidism, leading to the onset of hypercalcemia. The parathyroid glands are found to undergo hyperplastic or adenomatous changes and act autonomously with increased parathormone secretion not suppressed by feedback control. This entity is commonly associated with long-term secondary hyperparathyroidism states, such as chronic kidney disease, renal transplantation, and gastrointestinal malabsorption. The authors describe the case of a 50-year-old female with a history of biliopancreatic diversion surgery, renal lithiasis with recurrent obstructive pyelonephritis, and a work accident with significant limitation of mobility. She was referred to hospital consultation for a pathological fracture of the dorsal vertebra in the context of tertiary hyperparathyroidism due to long-term gastrointestinal malabsorption.
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