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Updated: Jun 9, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
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One-Year and Five-Year Outcomes in Medication Overuse Headache: A Real-World Study
Abouch Krymchantowski1, Carla Jevoux1, Ana Gabriela Krymchantowski1
1Department of Neurology, Headache Center of Rio, Rio de Janeiro, BRA.
Cureus
|October 28, 2024
Summary
Effective management of medication overuse headache (MOH) involves stopping overused medications and initiating preventive treatments. This study shows a significant reduction in headache days over five years with withdrawal therapy and preventive strategies.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Medication overuse headache (MOH) is a significant global health issue.
- Effective MOH management involves medication cessation, transition therapy, and preventive treatment.
- Chronic migraine with MOH presents complex treatment challenges.
Purpose of the Study:
- To evaluate the one-year and five-year efficacy of managing chronic migraine with MOH.
- To assess the impact of withdrawal therapy, conventional preventive medications, and anti-CGRP monoclonal antibodies.
Main Methods:
- A prospective, descriptive study conducted at a single tertiary center in Brazil.
- Inclusion of consecutive patients diagnosed with chronic migraine and MOH.
- Collection of demographic and clinical data at baseline and at one- and five-year follow-ups.
Main Results:
- 142 patients (116 female, 26 male, mean age 42.1) were followed for five years.
- Baseline average headache days per month (HDM) was 25.2.
- A ≥75% reduction in HDM was observed in 51.4% at one year and 70.4% at five years.
Conclusions:
- Discontinuation of overused medications combined with preventive strategies significantly reduces headache frequency in chronic migraine with MOH.
- Long-term follow-up demonstrates sustained benefits of withdrawal therapy and preventive treatments.
- Anti-CGRP pathway monoclonal antibodies may offer an additional therapeutic option.
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