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Characterizing Hematological Changes Following Repeated Exposure to Non-Targeted Low-Dose Ionizing Radiation in
Allison E Kennedy1,2, Ian S Dayes3,4, Sameer Parpia4
1Department of Medicine, Michael G. DeGroot School of Medicine, McMaster University, Hamilton, ON, Canada.
Dose-Response : a Publication of International Hormesis Society
|October 28, 2024
Summary
Low-dose radiation therapy showed minimal hematologic changes, with most blood cell counts returning to normal within three months. This study details these effects over a one-year follow-up period.
Area of Science:
- Oncology
- Hematology
- Radiation Oncology
Background:
- The hematological effects of low-dose radiation are not fully understood.
- Previous research indicated low-dose radiation was well-tolerated with minimal toxicity.
Purpose of the Study:
- To detail hematological changes during and after low-dose radiation treatment.
- To explore potential biomarkers for treatment success.
Main Methods:
- Participants (n=15) received low-dose radiation (150 mGy twice weekly for 5 weeks).
- Hematological parameters were monitored during treatment and for 12 months post-treatment.
- Monocyte activation marker CD64 was assessed.
Main Results:
- Minor, non-clinically significant decreases in leukocytes, platelets, and erythrocytes were observed at 12 months.
- T-cells, NK-cells, B-cells, and neutrophils decreased during treatment, returning to baseline by 3 months.
- Lower CD64 levels correlated with better cancer non-progression.
Conclusions:
- Low-dose radiation causes minor, transient hematological changes that mostly resolve within three months.
- CD64 may serve as a biomarker for predicting treatment response in patients receiving low-dose radiation.
