NMDAR Down-Regulation: Dual - Hit Molecular Target For COPD - Depression Comorbidity
Uriel Heresco-Levy1,2, Jacob Haviv1, Yehezkel G Caine1
1Herzog Medical Center, Jerusalem, Israel.
Journal of Inflammation Research
|October 28, 2024
Summary
Chronic obstructive pulmonary disease (COPD) and depression share inflammation pathways. Targeting N-methyl-D-aspartate receptors with D-cycloserine may treat both conditions simultaneously.
Area of Science:
- Pulmonary Medicine
- Neuroscience
- Psychiatry
Background:
- Chronic obstructive pulmonary disease (COPD) is a major cause of disability, often co-occurring with depression.
- Both COPD and depression involve chronic systemic inflammation, presenting a significant unmet treatment need.
- N-methyl-D-aspartate receptors (NMDAR) are implicated in CNS disorders and lung inflammation.
Purpose of the Study:
- To explore NMDAR as a unified molecular target for treating COPD-depression comorbidity.
- To investigate the potential of D-cycloserine to alleviate respiratory and depression symptoms.
Main Methods:
- Review of existing evidence on NMDAR function in COPD and depression.
- Analysis of D-cycloserine's known pharmacological effects (NMDAR antagonism, anti-inflammatory, antidepressant).
Main Results:
- Pathologic NMDAR up-regulation may contribute to both chronic lung injury and depression.
- D-cycloserine acts as a functional NMDAR antagonist with demonstrated antidepressant and anti-inflammatory properties.
Conclusions:
- NMDAR down-regulation presents a potential unified therapeutic target for COPD-depression comorbidity.
- D-cycloserine may offer a dual-action treatment for respiratory and depressive symptoms in COPD patients.
- The hypothesis may extend to other inflammatory disorders comorbid with depression.
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