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Azelaic Acid: Mechanisms of Action and Clinical Applications
Xiaoyue Feng1, Jianli Shang1, Zhengping Gu1
1R&D Department, Beijing UPROVEN Medical Technology Co., Ltd., Beijing, Daxing, People's Republic of China.
Abstract:
AZA is a non-phenolic, saturated dicarboxylic acid with nine carbon atoms, naturally produced by the yeast Malassezia. It has diverse physiological activities, including antibacterial, anti-keratinizing, antimelanogenic, antioxidant and anti-inflammatory effects. AZA is widely used in dermatology and is FDA-approved for treating papulopustular rosacea. It also shows significant efficacy in acne vulgaris and melasma. This review summarizes the mechanisms of action and clinical applications of AZA, aiming to provide theoretical support for its clinical and cosmetic use and to facilitate further research.
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