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Updated: Jun 9, 2025
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
The impact of sleep problems on cerebral aneurysm risk is mediated by hypertension: a mediated Mendelian
1Department of Pathology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Insights
Insomnia is a significant risk factor for cerebral aneurysms (CA), with hypertension acting as a mediator. Improving sleep quality may help prevent CA.
Area of Science:
- Neuroscience
- Cardiovascular Research
- Sleep Medicine
Background:
- Cerebral aneurysms (CA) are common vascular diseases with known risk factors like hypertension and smoking.
- While sleep problems are linked to cardiovascular disease, their causal relationship with CA remains under-researched.
Purpose of the Study:
- To investigate the causal relationship between specific sleep problems (snoring, insomnia, narcolepsy, daytime napping) and cerebral aneurysms (CA).
- To identify potential mediating factors, such as hypertension, in the relationship between sleep problems and CA.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) analysis to assess the causal link between sleep problems and CA.
- Employed multivariate MR (MVMR) to analyze potential confounders and mediators, specifically hypertension.
Main Results:
- A strong causal relationship was found between insomnia and CA (OR = 8.35, p = 7.772e-04), identifying insomnia as a potential risk factor.
- Hypertension was identified as a significant mediator between insomnia and CA, explaining 52.538% of the effect (OR = 3.05, p = 0.015).
Conclusions:
- Insomnia is a potential risk factor for developing cerebral aneurysms.
- Hypertension mediates the causal pathway between insomnia and CA.
- Targeting sleep problems and enhancing sleep quality could be a viable strategy for cerebral aneurysm prevention.
Introduction:
Cerebral aneurysm (CA) is a common vascular disease. The risk factors of CA include hypertension, smoking, and a family history of genetic predisposition. Although sleep-related problems have been found to have a strong association with cardiovascular disease, there is a lack of research regarding the causal relationship with cerebral aneurysms.
Methods:
In this study, we investigated the causal relationship between four sleep-related problems, including snoring, insomnia, narcolepsy, and napping during the day, and CA using a two-sample Mendelian randomization (MR) analysis. Moreover, the potential confounders before sleep problems and CA were further analyzed by multivariate MR (MVMR).
Results:
The causal relationship between insomnia and CA was obtained analytically by means of six MR analyses. There was a strong causal effect relationship between insomnia and CA, which suggests this as a potential risk factor [odds ratio (OR) = 8.35, 95% confidence interval (CI) = 2.422-28.791, p = 7.772e-04]. On this basis, hypertension was identified as a mediator between insomnia and CA by MVMR, with a mediating effect of 52.538% (OR = 3.05, 95% CI = 1.549-4.55, p = 0.015).
Conclusion:
The causal relationship between insomnia and CA was predicted using genetic variance data, and insomnia was found to be a potential risk factor. Furthermore, hypertension is a mediator between insomnia and CA. Therefore, focusing on sleep problems and improving sleep quality may be an active and effective strategy to prevent CA.
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