Perfluoroalkyl and polyfluoroalkyl substances and Cancer risk: results from a dose-response Meta-analysis
Jingxuan Yang1, Kui Zhang2, Jingyi Shi1
1Department of Physiology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041 People's Republic of China.
Journal of Environmental Health Science & Engineering
|October 28, 2024
Summary
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) exposure is linked to increased cancer risk, particularly genitourinary cancers. PFDA exposure shows a dose-dependent relationship with overall and breast cancer risk, highlighting PFASs as potential carcinogens.
Area of Science:
- Environmental Health
- Toxicology
- Epidemiology
Background:
- Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent environmental pollutants.
- The association between PFAS exposure and cancer development is debated, necessitating further investigation.
Purpose of the Study:
- To conduct a dose-response meta-analysis investigating the relationship between PFAS exposure and cancer risk.
- To quantify the effects of various PFASs on different cancer types.
Main Methods:
- A meta-analysis of 40 studies involving 748,188 participants was performed.
- Dose-response relationships were assessed using fixed-effects models and least-squares regression.
- Odds ratios (OR) and standardized mean differences (SMD) with 95% confidence intervals (CI) were employed.
Main Results:
- PFAS exposure, particularly PFDA, significantly elevates genitourinary cancer risk.
- PFDA exposure demonstrated a dose-dependent increase in overall and breast cancer risk.
- PFOS exposure was linked to increased cancer risk, and elevated PFOA levels were observed in breast cancer patients.
Conclusions:
- PFAS exposure represents a significant potential risk factor for cancer development.
- The carcinogenic potential of PFDA is dose-dependent, underscoring the importance of exposure levels.
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