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Updated: Jun 9, 2025

Assessing Bacterial Invasion of Cardiac Cells in Culture and Heart Colonization in Infected Mice Using Listeria monocytogenes
09:18

Assessing Bacterial Invasion of Cardiac Cells in Culture and Heart Colonization in Infected Mice Using Listeria monocytogenes

Published on: May 27, 2015

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Two Cases of Listeria monocytogenes-Induced Infective Endocarditis

Mengli Tang1, Xingbing Lu1, Yuxiao Li2

  • 1Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Infection and Drug Resistance
|October 28, 2024
PubMed

Insights

Listeria monocytogenes can cause severe endocarditis, particularly in patients with heart valve disease. Prompt diagnosis and combination antibiotic therapy with ampicillin and aminoglycosides are vital for successful treatment.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Microbiology

Background:

  • Listeria monocytogenes is a significant foodborne pathogen causing opportunistic infections.
  • Listeriosis presents with diverse clinical manifestations, including serious neurological and bloodstream infections.
  • Heart valve disease increases susceptibility to severe bacterial infections.

Observation:

  • This study details two cases of severe endocarditis caused by Listeria monocytogenes.
  • Patients presented with pre-existing heart valve disease, a known risk factor.
  • Diagnosis was confirmed through blood cultures and analysis of valve pus.

Findings:

  • Listeria monocytogenes was identified as the causative agent of severe endocarditis in both cases.
  • Blood and valve pus cultures confirmed the bacterial presence.
  • The severity of the infection highlights the pathogen's potential to affect cardiac structures.

Implications:

  • Early clinical suspicion and rapid diagnosis are critical for improving patient outcomes in listeriosis.
  • Combination therapy with ampicillin and aminoglycosides is the recommended treatment.
  • Understanding the link between Listeria monocytogenes and endocarditis is crucial for public health and clinical practice.
Keywords:
Listeria monocytogenesheart valve diseaseinfective endocarditis

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