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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

486
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Pro-tumor Activity Of Ints7 On Lung Adenocarcinoma Via Inhibiting Immune Infiltration And Activating P38mapk Pathway.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. The Pro-tumor Activity Of Ints7 On Lung Adenocarcinoma Via Inhibiting Immune Infiltration And Activating P38mapk Pathway.

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The pro-tumor activity of INTS7 on lung adenocarcinoma via inhibiting immune infiltration and activating p38MAPK pathway.

Xiang Li1, Feifei Lu1, Man Cao2

  • 1Department of Respiratory and Critical Care Medicine, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, 242 Guangji Road, Soochow, 215000, Jiangsu, P.R. China.

Scientific Reports
|October 28, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Downregulating INTS7 inhibits lung adenocarcinoma (LUAD) cell proliferation, invasion, and migration. Targeting INTS7 shows potential for LUAD therapy by affecting the p38MAPK pathway and immune cell infiltration.

Keywords:
INTS7Immune infiltrationLung adenocarcinoma

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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Lung adenocarcinoma (LUAD) is a leading cause of cancer mortality.
  • Previous research identified upregulated INTS7 expression in LUAD, but its functional role is unclear.

Purpose of the Study:

  • To elucidate the molecular mechanisms of INTS7 in LUAD progression.
  • To investigate the potential of targeting INTS7 as a therapeutic strategy for LUAD.

Main Methods:

  • Gene knockdown using shRNA in A549 cells.
  • In vitro assays (CCK8, transwell) and in vivo xenograft models.
  • Bioinformatics, western blot, immunofluorescence, and nomogram construction.

Main Results:

  • INTS7 downregulation suppressed LUAD cell proliferation, invasion, migration, and tumor growth.
  • The p38MAPK pathway was identified as a key mediator of INTS7's function.
  • INTS7 expression correlated with specific immune cell infiltration patterns (macrophages M2, memory B cells, mast cells).

    • Conclusions:

    • INTS7 plays a pro-cancer role in LUAD through the p38MAPK pathway.
    • INTS7 influences the tumor immune microenvironment.
    • Targeting INTS7 presents a promising therapeutic avenue for LUAD treatment.