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Preliminary Results of Iran Premature Coronary Artery Disease (IPAD study) and Implementation of IPAD Biobank: A
Ehsan Zarepur1, Noushin Mohammadifard2, Reza Nedaeinia1
1Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
The Iran Premature Coronary Artery Disease (IPAD) study established a large biobank for premature coronary artery disease (PCAD) research. This biobank facilitates investigations into PCAD, particularly gene-environment interactions across diverse Iranian ethnicities.
Area of Science:
- Cardiovascular Disease Research
- Biobanking and Translational Science
- Population Health and Epidemiology
Background:
- Premature Coronary Artery Disease (PCAD) presents unique challenges in Asian populations.
- The Iran Premature Coronary Artery Disease (IPAD) study is a pioneering initiative in Asia.
- IPAD investigates PCAD across diverse ethnic groups and multiple Iranian cities.
Purpose of the Study:
- To establish a high-quality biobank for PCAD research.
- To describe the methodology behind the IPAD biobank's creation.
- To present preliminary findings from the IPAD study.
Main Methods:
- A case-control study design involving patients with documented coronary angiography.
- Inclusion criteria: males ≤60 years, females ≤70 years with significant coronary stenosis.
- Collection of extensive biosamples (serum, blood, saliva, urine, feces) stored at -80°C.
Main Results:
- Enrollment completed with 1221 controls and 1702 cases.
- Mean patient age was 51.1±8.2 years, with 43% women.
- Approximately 30,000 biosamples from various ethnicities are preserved in the IPAD biobank.
Conclusions:
- The IPAD biobank is a valuable resource for PCAD research.
- Facilitates studies on gene-environment interactions in PCAD.
- Supports research into ethnic variations in PCAD etiology.
Background:
Iran Premature Coronary Artery Disease (IPAD) is one of the first and largest studies of its kind in Asia that investigates different aspects of premature coronary artery disease (PCAD) in different ethnic groups in multiple cities. In this paper, we aim to describe the IPAD biobank establishment and present some preliminary results of the IPAD study.
Methods:
This case-control study was conducted on patients with documented angiography from different ethnicities in more than ten cities of Iran (males aged 60 years and below and females aged 70 years and below). Patients with coronary artery stenosis of more than 75% in at least one vessel (or left-main stenosis of more than 50%) were defined as the case group and patients with normal coronary angiography were considered as the control group. In addition to completing questionnaires and performing physical measurements, samples of serum, buffy coat, plasma, whole blood, saliva, urine, and feces were stored in the freezer at -80 °C.
Results:
The mean age of patients was 51.1±8.2, of which 43% were women. There were 1221 people in the control group and 1702 in the case group. Our enrollment is completed and data entry and transferring biosamples from different cities is still ongoing. About 30000 biosamples of different ethnicities are saved in the IPAD biobank.
Conclusion:
This study aims to develop a high-quality biobank and facilitate research on different aspects of PCAD, especially gene-environment interaction regarding ethnicity.
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