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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
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The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
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Related Experiment Video

Updated: Jun 9, 2025

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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ABO Blood Type and Short-Term Mortality in Patients With Infection-Associated Disseminated Intravascular Coagulation.

Simon Flæng1,2, Asger Granfeldt2,3, Kasper Adelborg1

  • 1Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.

European Journal of Haematology
|October 28, 2024
PubMed
Summary

This study found no significant difference in short-term mortality for patients with infection-associated disseminated intravascular coagulation (DIC) across different ABO blood types. ABO blood group does not appear to be a major factor in DIC outcomes.

Keywords:
ABO blood groupdisseminated intravascular coagulationmortalityprognosis

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Disseminated intravascular coagulation (DIC) is a severe coagulation disorder.
  • Infection-associated DIC is a common and life-threatening complication.
  • The role of ABO blood type in DIC outcomes remains unclear.

Purpose of the Study:

  • To investigate the association between ABO blood type and short-term mortality in patients with infection-associated DIC.
  • To determine if specific blood types influence survival rates in this patient population.

Main Methods:

  • Utilized the Danish Disseminated Intravascular Coagulation (DANDIC) cohort.
  • Focused on a subcohort of patients with infection-associated DIC.
  • Analyzed 30-day and 90-day all-cause mortality using Kaplan-Meier estimates and logistic regression, adjusting for confounders. Blood type O served as the reference.

Main Results:

  • The study included 1853 patients with infection-associated DIC.
  • 30-day mortality rates varied between 38.6% and 42.5%.
  • Odds ratios for 30-day mortality showed no significant differences across ABO blood types compared to type O (e.g., Type A: 1.15, 95% CI 0.92-1.42).

Conclusions:

  • No clinically significant differences in short-term mortality were observed among ABO blood types in patients with infection-associated DIC.
  • ABO blood group is unlikely to be a major prognostic factor for short-term survival in this condition.