Related Experiment Video
Updated: Jun 9, 2025
Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
ABO Blood Type and Short-Term Mortality in Patients With Infection-Associated Disseminated Intravascular Coagulation
Simon Flæng1,2, Asger Granfeldt2,3, Kasper Adelborg1
1Department of Clinical Epidemiology, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.
Insights
This study found no significant difference in short-term mortality for patients with infection-associated disseminated intravascular coagulation (DIC) across different ABO blood types. ABO blood group does not appear to be a major factor in DIC outcomes.
Area of Science:
- Hematology
- Infectious Diseases
- Critical Care Medicine
Background:
- Disseminated intravascular coagulation (DIC) is a severe coagulation disorder.
- Infection-associated DIC is a common and life-threatening complication.
- The role of ABO blood type in DIC outcomes remains unclear.
Purpose of the Study:
- To investigate the association between ABO blood type and short-term mortality in patients with infection-associated DIC.
- To determine if specific blood types influence survival rates in this patient population.
Main Methods:
- Utilized the Danish Disseminated Intravascular Coagulation (DANDIC) cohort.
- Focused on a subcohort of patients with infection-associated DIC.
- Analyzed 30-day and 90-day all-cause mortality using Kaplan-Meier estimates and logistic regression, adjusting for confounders. Blood type O served as the reference.
Main Results:
- The study included 1853 patients with infection-associated DIC.
- 30-day mortality rates varied between 38.6% and 42.5%.
- Odds ratios for 30-day mortality showed no significant differences across ABO blood types compared to type O (e.g., Type A: 1.15, 95% CI 0.92-1.42).
Conclusions:
- No clinically significant differences in short-term mortality were observed among ABO blood types in patients with infection-associated DIC.
- ABO blood group is unlikely to be a major prognostic factor for short-term survival in this condition.
Background:
Disseminated intravascular coagulation (DIC) is a devastating disease of the coagulation system. We examined the association between ABO blood type and short-term mortality in patients with infection-associated DIC.
Methods:
The study cohort was drawn from the Danish Disseminated Intravascular Coagulation (DANDIC) cohort. Our subcohort was restricted to patients with infection-associated DIC. All-cause 30-day and 90-day mortality were computed by Kaplan-Meier estimates and odds ratios between ABO blood types were examined using logistic regression analysis adjusted for age, sex, comorbidity, and location of infection. Blood type O was used as a reference.
Results:
The DANDIC cohort included 3023 patients with DIC. Among these, 1853 (61%) had infection-associated DIC. Data on ABO blood type were unavailable in 34 patients (1.8%), who were excluded. The median age was 68 years and 58.2% were males. The 30-day mortality ranged between 38.6% and 42.5% and the 30-day mortality odds ratios were 1.15 (95% confidence interval (CI), 0.92-1.42) for blood type A; 0.84 (95% CI, 0.49-1.43) for AB; and 0.95 (95% CI, 0.67-1.33) for B compared to blood type O.
Conclusions:
We found no clinically meaningful difference in short-term mortality between the various ABO blood types in patients with infection-associated DIC.
Related Concept Videos
02:45Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
01:15Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
01:10Blood Typing
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
01:24Disorders of Hemostasis
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
01:12The ABO Blood Group
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins