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  11. Prognostic Importance Of Preoperative Albumin-to-alkaline Phosphatase Ratio In Colorectal Cancer Patients

Prognostic importance of preoperative albumin-to-alkaline phosphatase ratio in colorectal cancer patients

Mehmet Reşit Sönmez1, Elif Tuncay1, İsa Caner Aydin1

  • 1TR University of Health Sciences, Ministry of Health Kartal Kosuyolu High Specialization Training, and Research Hospital Gastroenterological Surgery Clinic.

Polski Przeglad Chirurgiczny
|October 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

The albumin-alkaline phosphatase ratio (AAPR) was investigated as a prognostic biomarker for colorectal cancer (CRC). This study found no significant evidence that AAPR predicts overall survival in CRC patients.

Area of Science:

  • Oncology
  • Biomarker Research
  • Gastroenterology

Background:

  • Colorectal cancer (CRC) prognosis relies on clinical stage and histology, but survival varies.
  • There is a need for additional prognostic biomarkers, especially accessible serum biomarkers.
  • The albumin-alkaline phosphatase ratio (AAPR) shows promise in other cancers but is underexplored in CRC.

Purpose of the Study:

  • To evaluate the prognostic value of the albumin-alkaline phosphatase ratio (AAPR) in patients with colorectal cancer (CRC).

Main Methods:

  • Retrospective analysis of data from 358 surgically treated CRC patients.
  • Utilized Receiver Operating Characteristic (ROC) curve analysis to assess AAPR's predictive power for mortality.
  • Employed Kaplan-Meier and log-rank tests to analyze overall survival (OS).
Keywords:
albumin-alkaline phosphatase ratiobiomarkerscolorectal cancerprognosis

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Main Results:

  • An AAPR cut-off of 0.67 predicted mortality with 17.54% sensitivity and 92.22% specificity.
  • Patients with lower AAPR showed a trend towards shorter survival, but the difference was not statistically significant (P = .112).

Conclusions:

  • This study did not find sufficient evidence to support the albumin-alkaline phosphatase ratio (AAPR) as a prognostic factor for colorectal cancer patients.
  • Further research may be needed to explore other potential roles or combinations of biomarkers in CRC prognosis.
surgery