Related Experiment Video

Updated: Jun 9, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

1.8K

Predictive role of Oxford Classification for prognosis in children with IgA nephropathy: a systematic review and

Xiaohang Liu1, Chen Wang2, Zimo Sun3

  • 1Center for Clinical Epidemiology and Evidence-based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children Health, Beijing, China.

Renal Failure
|October 28, 2024
PubMed

Insights

The Oxford Classification helps predict IgA nephropathy (IgAN) in children. Specific lesions like M1, S1, and T1/T2 indicate a higher risk of poor kidney prognosis in pediatric IgAN patients.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Immunology

Background:

  • The Oxford Classification is a prognostic tool for IgA nephropathy (IgAN).
  • Most existing research on the Oxford Classification in IgAN focuses on adult populations.
  • There is a need to evaluate its predictive value in pediatric IgAN cases.

Purpose of the Study:

  • To assess the predictive accuracy of the Oxford Classification for kidney prognosis in pediatric IgAN patients.
  • To synthesize evidence from cohort studies on the association between Oxford Classification lesions and kidney outcomes in children with IgAN.

Main Methods:

  • A meta-analysis was conducted on cohort studies examining the Oxford Classification and kidney prognosis in pediatric IgAN.
  • Studies included were those associating five Oxford Classification lesions with poor kidney prognosis (GFR G2-G5) per KDIGO guidelines.
  • Hazard ratios were synthesized using random-effects models, and risk of bias was assessed using the Newcastle-Ottawa scale.

Main Results:

  • Fourteen articles comprising 5679 pediatric IgAN patients were analyzed.
  • The M1 lesion was significantly associated with an increased risk of poor kidney prognosis (pooled HR 1.79).
  • S1 and T1/T2 lesions also increased the risk of poor kidney prognosis (pooled HRs 2.13 and 2.64, respectively).
  • C1/C2 lesions were linked to increased risk in Asian and other populations; E1 showed marginal association.

Conclusions:

  • The Oxford Classification is a valuable prognostic indicator for IgA nephropathy in pediatric patients.
  • Specific lesions (M1, S1, T1/T2, C1/C2) are associated with worse kidney outcomes in children with IgAN.
  • Further research may clarify the role of the E1 lesion in pediatric IgAN prognosis.
Abstract

Keywords:
IgA nephropathyMEST-COxford Classificationpediatric

More Related Videos

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy08:08

Cell-based Assay Protocol for the Prognostic Prediction of Idiopathic Scoliosis Using Cellular Dielectric Spectroscopy

Published on: October 16, 2013

10.6K
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring07:35

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring

Published on: June 23, 2015

11.5K

Related Concept Videos

Receiver Operating Characteristic Plot01:15

Receiver Operating Characteristic Plot

A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
92