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Updated: Jun 9, 2025

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
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Tertiary Lymphoid Structure in Dental Pulp: The Role in Combating Bacterial Infections.

Ruiqi Li1, Fan Gu1,2, Linlin Peng1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 28, 2024
PubMed
Summary

Tertiary lymphoid structures (TLS) form in inflamed dental pulp, driven by CC chemokine ligand 3 (CCL3). This study reveals TLS markers and immune cell changes in pulpitis, offering insights into infection response.

Keywords:
carieschemokinesdental pulpimmune cellspulpitistertiary lymphoid structure (TLS)

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Area of Science:

  • Immunology
  • Oral Biology

Background:

  • Tertiary lymphoid structures (TLS) are implicated in various diseases, but their formation and role in immune responses are not fully understood.
  • The unique structure of dental pulp facilitates a directional immune response to infection, making it a suitable model for studying TLS.

Purpose of the Study:

  • To investigate the presence and characteristics of TLS in human dental pulp during inflammation.
  • To identify molecular drivers and immune cell dynamics associated with TLS formation in pulpitis.

Main Methods:

  • Single-cell RNA sequencing of healthy and inflamed human dental pulp.
  • Multiple immunofluorescence staining.
  • Analysis of a mouse model of pulpitis.

Main Results:

  • Inflamed dental pulp exhibits known TLS markers (CCL19, LAMP3, CCR7, CD86) and increased immune cell populations with enhanced communication.
  • Typical TLS structures were observed in pulpitis, correlating with high CC chemokine ligand 3 (CCL3) expression, suggesting it as a key driver.
  • TLS formation was also confirmed in a mouse model of pulpitis.

Conclusions:

  • TLS are present in inflamed dental pulp (pulpitis) and are associated with specific immune cell changes and molecular markers.
  • CC chemokine ligand 3 (CCL3) may play a crucial role in the formation of TLS in the dental pulp during infection.
  • These findings enhance understanding of TLS formation and function in the context of dental pulp infections.