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  9. Predictive And Prognostic Markers
  11. The Prognostic Role Of Survivin Expression In Breast Cancer: A Systematic Review And Meta-analysis

The prognostic role of survivin expression in breast cancer: A systematic review and meta-analysis

Betul Bolat Kucukzeybek1, Yuksel Kucukzeybek2, Yasemin Basbinar3

  • 1Department of Pathology, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey.

Medicine
|October 28, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Survivin expression may indicate poor prognosis in breast cancer patients, suggesting its potential as a new prognostic marker. This meta-analysis supports survivin

Area of Science:

  • Oncology
  • Molecular Biology
  • Biomarker Research

Background:

  • Breast cancer heterogeneity necessitates novel prognostic markers beyond current clinicopathological and genomic factors.
  • Survivin, an apoptosis inhibitor, is a potential prognostic marker, but existing studies show inconsistent results.
  • This meta-analysis addresses the need for a comprehensive evaluation of survivin's prognostic significance in breast cancer.

Purpose of the Study:

  • To evaluate the prognostic impact of survivin expression on overall survival (OS) and disease-free survival (DFS) in breast cancer patients.
  • To synthesize findings from existing studies using a meta-analysis approach.
  • To determine if survivin expression can serve as a reliable prognostic marker for breast cancer.

Main Methods:

  • Systematic literature search of PubMed, Embase, and Cochrane databases for studies on survivin expression and breast cancer survival.

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  • Meta-analysis of 24 studies for OS and 15 studies for DFS, including those using immunohistochemistry or polymerase chain reaction for detection.
  • Statistical analysis performed using Stata and JAMOVI to assess heterogeneity and pooled survival outcomes.

    • Main Results:

    • No significant heterogeneity was found across the included studies.
    • Survivin expression was associated with poorer overall survival (HR 1.23) and disease-free survival (HR 0.89), indicating a negative prognostic impact.
    • This association remained consistent regardless of the detection method (immunohistochemistry or polymerase chain reaction).

    Conclusions:

    • Survivin expression demonstrates prognostic significance in breast cancer patients.
    • The findings support survivin as a potential prognostic marker to aid in treatment decisions.
    • Further validation may enhance its clinical utility in breast cancer management.