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Predictive tests for Meniere's disease.

A W Morrison

    The American Journal of Otology
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Electrocochleography and glycerol dehydration tests offer prognostic insights for Meniere's disease. Abnormalities in these tests predict disease progression and surgical outcomes, aiding in management strategies.

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    Area of Science:

    • Otolaryngology
    • Audiology
    • Neurosurgery

    Background:

    • Meniere's disease is characterized by endolymphatic hydrops, often becoming bilateral.
    • Prognostic indicators for Meniere's disease are crucial for patient management and surgical planning.

    Purpose of the Study:

    • To evaluate the prognostic value of electrocochleography and glycerol dehydration tests in Meniere's disease.
    • To explore the utility of vestibular aqueduct tomography, acetazolamide cochlear hydration tests, plasma osmolality, and otoadmittance in diagnosing and understanding Meniere's disease.
    • To investigate potential immune system involvement in Meniere's disease.

    Main Methods:

    • Electrocochleography (ECoG) and glycerol dehydration tests were performed.
    • Vestibular aqueduct tomography, acetazolamide cochlear hydration tests, and plasma osmolality studies were conducted.

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  • Otoadmittance measurements and serum immune complex/complement level assessments were performed.

    • Main Results:

    • Abnormal ECoG waveforms correlate with a poorer prognosis.
    • Significant hearing threshold changes after glycerol dehydration predict outcomes post-endolymphatic sac surgery.
    • Otoadmittance studies revealed distinct baseline values in fluctuant Meniere's disease and hydrops, with abnormalities also present in the contralateral ear of "unilateral" cases.
    • Elevated serum immune complexes and complement levels were observed, though their significance remains unclear.

    Conclusions:

    • Electrocochleography and glycerol tests are valuable prognostic tools for Meniere's disease.
    • Various diagnostic tests, including otoadmittance and hydration challenges, aid in understanding hydrops and disease activity.
    • Further research is needed to clarify the role of immune factors in Meniere's disease pathogenesis.