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Relationship between relative fat mass and infertility: A cross-sectional study
Xi Zhao1, Yue Wu2, Huangyu Hu3
1Department of Integrated Traditional Chinese and Western Medicine, Nanchong Central Hospital, Capital Medical University Affiliated Beijing Anzhen Hospital Nanchong Hospital, The Second Clinical Medical College, North Sichuan Medical College, Nanchong, China.
Medicine
|October 28, 2024
Summary
Higher relative fat mass (RFM) is linked to increased infertility risk in US women. This study found a nonlinear association, suggesting RFM may help manage infertility in obese women.
Area of Science:
- Reproductive Health
- Obesity Research
- Biostatistics
Background:
- Obesity is linked to infertility.
- Relative Fat Mass (RFM) is a better body fat indicator than Body Mass Index (BMI).
- The association between RFM and infertility requires further investigation.
Purpose of the Study:
- To examine the relationship between RFM and infertility in US women aged 20-44.
- To determine if RFM is a significant predictor of infertility.
Main Methods:
- Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2018.
- Multiple logistic regression and generalized additive models.
- Two-stage linear regression to identify threshold effects.
Main Results:
- A 6% increase in infertility risk for every unit increase in RFM (OR=1.06).
- A nonlinear relationship with breakpoints at RFM values of 31.04 and 48.4.
- Positive association between RFM and infertility within the 31.04-48.4 range.
Conclusions:
- RFM shows a significant nonlinear association with infertility in women.
- RFM may serve as an alternative to BMI for managing infertility in obese women.
- Further prospective studies are needed to confirm these findings.
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