Related Experiment Video
Updated: Jun 9, 2025
12:19
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
861
Cancer Trends in Inborn Errors of Immunity: A Systematic Review and Meta-Analysis
Saba Fekrvand1,2, Hassan Abolhassani1,3, Zahra Hamidi Esfahani1,2
1Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Journal of Clinical Immunology
|October 28, 2024
Summary
Cancer is more common in patients with inborn errors of immunity (IEI) due to immune defects. This review highlights that cancer incidence in IEI patients depends on specific genetic defects, suggesting personalized screening and treatment can improve outcomes.
Area of Science:
- Immunology
- Oncology
- Genetics
Background:
- Patients with inborn errors of immunity (IEI) face a higher risk of developing cancer due to compromised immune systems.
- Cancer is a significant cause of mortality among individuals with IEI.
Approach:
- Systematic review and meta-analysis of demographic, genetic, and cancer data from 4607 IEI patients with malignancy history.
- Searched Embase, Web of Science, PubMed, and Scopus databases for studies published until September 2023.
Key Points:
- Hematologic/blood cancers, particularly diffuse large B-cell lymphoma, were the most frequent malignancies.
- ATM deficiency was most common among monogenic IEI defects, while NBS1 deficiency showed the highest cancer frequency rate.
- BRCA2 deficiency was associated with the earliest cancer onset, lowest cure rates, and highest fatality.
Conclusions:
- Overall cancer frequency in reviewed IEI cases was 11.1-12.0%.
- Cancer incidence in IEI is strongly linked to specific molecular and pathway defects.
- Individualized early screening and tailored treatments are crucial for improving prognosis in IEI patients.
Keywords:
DNA Repair DefectsHematologic CancersInborn Errors of ImmunityMalignancyPrimary Immunodeficiency DiseasesMore Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
486
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
486
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:20Mismatch Repair
4.8K
Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
4.8K
01:30Cancer Vaccines
342
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
342
01:25Mutagenicity and Carcinogenicity
1.2K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.2K