Related Experiment Video
Updated: Jun 9, 2025
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
Diagnostic Accuracy of PSMA PET-Guided Prostate Biopsy in Prostate Cancer-A Systematic Review and Meta-analysis
Piyush Aggarwal1, Vinisha Gunasekaran1, Harmandeep Singh1
1From the Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Purpose:
Early diagnosis and treatment of prostate cancer (PC) are crucial for effective management and improved patient outcomes. Newer imaging modalities like prostate-specific membrane antigen PET have shown superior diagnostic performance in detecting PC and clinically significant PC (csPC). This systematic review and meta-analysis aims to synthesize evidence on the diagnostic performance of PSMA PET-guided prostate biopsy in detecting PC and csPC.
Patients And Methods:
The study followed the PRISMA-DTA guidelines. Using a predefined search strategy, 3 databases (PubMed, Embase, and Web of Science) were systematically searched using appropriate keywords. A meta-analysis was conducted using diagnostic accuracy parameters of the included studies. Risk of bias assessment was done using the QUADAS-2 tool.
Results:
Out of 378 articles, 20 were assessed for full-text screening and 10 articles with 874 patients were finally included. Eight studies reported a pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of 0.90 (95%confidence interval [CI], 0.82-0.95), 0.93 (95% CI, 0.57-0.99), 12.3 (95% CI, 1.5-98.9), 0.10 (95% CI, 0.05-0.20), and 117 (95% CI, 12-1178), respectively, for detecting PC using PSMA PET-guided prostate biopsy with an area under the summary receiver operating characteristics curve of 0.94 (95% CI, 0.92-0.96). Similarly, 6 studies reported a pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of 0.89 (95% CI, 0.82-0.94), 0.65 (95% CI, 0.49-0.79), 2.6 (95% CI, 1.6-4.1), 0.17 (95% CI, 0.09-0.31), and 15 (95% CI, 6-41), respectively, for detecting csPC using PSMA PET-guided prostate biopsy with area under summary receiver operating characteristics curve of 0.86 (95% CI, 0.82-0.88).
Conclusions:
PSMA PET-guided prostate biopsy has a high diagnostic accuracy in detecting PC and csPC in patients with clinical suspicion of PC, and provides a 1-stop solution for early diagnosis and staging of PC.
