Association Between Systemic Immune-Inflammation Index and Psoriasis, Psoriasis Comorbidities, and All-Cause...

Area of Science:

• Immunology
• Dermatology
• Epidemiology

Background:

• The relationship between the systemic immune-inflammation index (SII) and psoriasis, including its comorbidities and prognosis, remains unclear.
• Investigating this association can provide insights into the inflammatory pathways involved in psoriasis and its systemic impact.

Purpose of the Study:

• To investigate the correlation between SII and the prevalence of psoriasis.
• To examine the association between SII and psoriasis comorbidities, specifically metabolic syndrome (MetS).
• To assess the relationship between SII and all-cause mortality in individuals with psoriasis.

Main Methods:

• Analysis of data from 21,431 participants across multiple National Health and Nutrition Examination Survey (NHANES) cycles (2003-2014).
• Weighted multivariate logistic regression models were used to analyze the association between SII and psoriasis/comorbidities.
• Weighted COX regression was employed to determine hazard ratios for all-cause mortality, with follow-up data extending to December 31, 2019.

Main Results:

• A positive association was found between SII and psoriasis prevalence (OR=1.20, p=0.01) in the fully adjusted model.
• Among psoriasis patients, SII was significantly associated with metabolic syndrome (OR=1.68, p=0.004) and all-cause mortality (HR=1.48, p=0.01).
• These associations remained consistent across various sensitivity and subgroup analyses, including when SII was analyzed categorically.

Conclusions:

• The study suggests a positive association between higher SII levels and the prevalence of psoriasis.
• Elevated SII in psoriasis patients is linked to a higher likelihood of metabolic syndrome and increased risk of all-cause mortality.