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UGT1A1 Testing for the Risk of Nanoliposomal Irinotecan-Related Toxicity

Yao Liang1, Yuichi Ando1

  • 1Yao Liang, MD, Nagoya University Hospital, Nagoya-Shi, Japan; and Yuichi Ando, MD, PhD, Nagoya University Hospital, Nagoya-Shi, Japan.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
|October 28, 2024
PubMed
Abstract

No abstract available in PubMed .

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...

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