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[Biomarkers in acute coronary syndromes: from the origins to the present]

E A Okisheva1, O I Trushina1

  • 1Sechenov First Moscow State Medical University (Sechenov University).

Terapevticheskii Arkhiv
|October 28, 2024
PubMed

Insights

Early diagnosis of cardiomyocyte damage using biomarkers significantly improves outcomes for patients with acute coronary syndrome. This approach aids in better patient prognosis and efficient hospital resource allocation.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Diagnostics

Background:

  • Acute coronary syndrome (ACS) is a primary cause of mortality.
  • ACS affects patients with coronary artery disease, diabetes, chronic kidney disease, and inflammatory conditions.
  • Early detection of cardiomyocyte damage is crucial for patient outcomes.

Purpose of the Study:

  • To review the evolution of myocardial damage and necrosis markers.
  • To highlight the clinical impact of these biomarkers in modern practice.
  • To discuss the benefits of early diagnosis in ACS management.

Main Methods:

  • Literature review on myocardial damage markers.
  • Analysis of clinical practice evolution.
  • Discussion of diagnostic marker introduction and impact.

Main Results:

  • Markers of myocardial damage have significantly advanced clinical practice.
  • Early diagnosis improves patient prognosis in atherosclerotic coronary artery disease.
  • Accurate diagnosis facilitates timely discharge for patients without acute cardiovascular pathology.

Conclusions:

  • The development and adoption of myocardial necrosis markers have transformed ACS care.
  • Improved diagnostic tools enhance patient management and prognosis.
  • Continued research in cardiac biomarkers is vital for cardiovascular medicine.

Keywords:
acute coronary syndromebiomarkerdiagnosisischemiamyocardial infarctionmyocardial injuryprognosistransaminasestroponin

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