Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

12.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
12.6K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

322
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
322

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global, regional and national burden and trends of non-alcoholic fatty liver disease in women of reproductive age from 1990 to 2021: Insights from the Global burden of disease study 2021.

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology·2026
Same author

Benchmarking public large language model responses to patient-facing inflammatory bowel disease questions: informational quality, transparency proxies, and readability.

Frontiers in public health·2026
Same author

Current status survey and risk factor analysis of metabolic dysfunction-associated steatotic liver disease among adolescents in Hainan Province.

Scientific reports·2026
Same author

YTHDC2 Deficiency Exacerbates Ulcerative Colitis by Stabilizing RBMS1 mRNA to Drive Epithelial Ferroptosis.

Inflammation·2026
Same author

OSMR coordinates a self-perpetuating circuit linking chemoresistance and neutrophil-driven immunosuppression in gastric cancer.

Neoplasia (New York, N.Y.)·2026
Same author

A Bibliometric Analysis of Research Trends and Collaborative Networks in Gastric Cancer and Helicobacter Pylori Studies.

Journal of gastrointestinal cancer·2026

Related Experiment Video

Updated: Jun 9, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K

Evaluating the association between immunological proteins and common intestinal diseases using a bidirectional

Ziwei Wang1, Qiuai Shu2, Jian Wu3

  • 1Department of Gastroenterology, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Shaanxi Key Laboratory of Gastrointestinal Motility Disorders, Xi'an Jiaotong University, Xi'an, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an, China; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China.

Cytokine
|October 28, 2024
PubMed
Summary

This study found links between immune proteins and gut diseases. Interleukin-1 beta may lower irritable bowel syndrome risk, while Interleukin-6 and Tumor Necrosis Factor-alpha are linked to inflammatory bowel disease and colorectal cancer risks, respectively.

Keywords:
Colorectal cancerImmunological proteinsInflammatory bowel diseaseIntestinal homeostasisIrritable bowel syndromeMendelian randomization

More Related Videos

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.0K
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

19.4K

Related Experiment Videos

Last Updated: Jun 9, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.0K
Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

19.4K

Area of Science:

  • Immunology
  • Gastroenterology
  • Genetics

Background:

  • Intestinal homeostasis relies on balanced immunological proteins.
  • Dysregulation of these proteins is implicated in irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and colorectal cancer (CRC).
  • Causal links between specific immune proteins and these diseases require further elucidation.

Purpose of the Study:

  • To investigate potential causal relationships between immunological proteins and common intestinal diseases (IBS, IBD, CRC).
  • To utilize Mendelian randomization to infer genetic predispositions and their association with disease risk.
  • To identify specific immune proteins that may serve as therapeutic targets.

Main Methods:

  • Bidirectional two-sample Mendelian randomization analysis was employed.
  • Genome-wide association study (GWAS) summary statistics for IBS, IBD, and CRC were obtained from public databases.
  • Multiple sensitivity analyses and Benjamini-Hochberg correction were used to ensure result robustness.

Main Results:

  • Interleukin-1 beta (IL-1β) showed a significant association with decreased IBS risk (OR = 0.783, adjusted P = 0.048).
  • Genetic predisposition to IBS was linked to reduced levels of Interleukin-25 (IL-25) (β = -0.233, adjusted P = 0.047).
  • Genetic predisposition to IBD correlated with elevated Interleukin-6 (IL-6) levels (β = 0.046, adjusted P = 0.010).
  • Tumor Necrosis Factor-alpha (TNF-α) levels were associated with an increased risk of CRC (OR = 1.252, adjusted P = 0.047).

Conclusions:

  • Specific immunological proteins are associated with the risk and progression of common intestinal diseases.
  • Findings suggest potential roles for IL-1β, IL-25, IL-6, and TNF-α in the pathogenesis of IBS, IBD, and CRC.
  • These associations offer insights for developing targeted immunomodulatory therapies for intestinal diseases.