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Body mass index trajectories from birth to early adulthood and lung function development

  • 0Division of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China gang.wang@ki.se.
The European Respiratory Journal +

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October 28, 2024

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October 28, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Maintaining a normal body mass index (BMI) from childhood is crucial for long-term lung health. Studies show that trajectories of BMI significantly impact lung function development throughout adolescence and into adulthood.

Area Of Science

  • Pediatric pulmonology
  • Growth and development studies
  • Obesity research

Background

  • Limited research exists on how body mass index (BMI) trajectories throughout childhood and adolescence affect lung function.
  • Understanding these long-term effects is essential for developing effective public health strategies.

Purpose Of The Study

  • To investigate the association between different body mass index (BMI) z-score trajectories from birth to 24 years and lung function at age 24.
  • To identify specific BMI patterns linked to impaired lung function development.

Main Methods

  • Prospective study of the Swedish BAMSE birth cohort (n=3204).
  • Latent class mixture modeling to identify BMI z-score trajectories.
  • Spirometry (pre- and post-bronchodilator) and lung clearance index (LCI) measured at age 24.
  • Urinary metabolomics analyzed at age 24.

Main Results

  • Six distinct BMI trajectory groups were identified.
  • Accelerated BMI increase was associated with reduced FEV1/FVC ratio and elevated LCI.
  • Persistent high BMI was linked to lower FEV1/FVC growth and increased LCI.
  • Persistent low BMI was associated with reduced FEV1/FVC and impaired lung function growth.
  • Histidine metabolites correlated with FEV1 measures.

Conclusions

  • Childhood BMI trajectories significantly influence lung function development up to adulthood.
  • Interventions promoting normal BMI in childhood may enhance long-term lung health.
  • Specific BMI patterns, like accelerated increase or persistent high levels, are detrimental to lung function.

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