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Updated: Jun 9, 2025

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ANGPTL4-A protein involved in glucose metabolism, lipid metabolism, and tumor development

Zhilong Xu1, Gening Jiang1

  • 1Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

The Journal of Gene Medicine
|October 28, 2024
PubMed

Insights

Angiopoietin-like 4 (ANGPTL4) is crucial for lipid and glucose metabolism. This review highlights ANGPTL4's role in metabolic regulation and tumor growth, suggesting its potential as a therapeutic target.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Metabolic Regulation

Background:

  • Angiopoietin-like 4 (ANGPTL4) was first identified in 2000 for its role in lipid metabolism.
  • Subsequent research revealed ANGPTL4's involvement in diverse biological processes, including glucose metabolism, angiogenesis, and wound healing.

Purpose of the Study:

  • To provide a comprehensive overview of ANGPTL4's fundamental role in metabolic regulation.
  • To examine the impact of ANGPTL4 on tumor growth.

Main Methods:

  • Literature review of studies on ANGPTL4.
  • Analysis of ANGPTL4's functions in various biological systems.

Main Results:

  • ANGPTL4 plays a significant role in regulating both lipid and glucose metabolism.
  • ANGPTL4 influences key aspects of tumor biology, including growth and progression.

Conclusions:

  • ANGPTL4 is a key regulator of metabolic homeostasis.
  • Understanding ANGPTL4's dual role in metabolism and cancer offers potential for novel therapeutic strategies.
Keywords:
ANGPTL4metabolic reprogrammingmetabolismtumor growth

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