Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

227
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
227
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

486
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
486

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Short-term effects of exercise therapy on pulmonary function and exercise tolerance in patients with mild to moderate adolescent idiopathic scoliosis: a meta-analysis of randomized controlled trial.

Frontiers in sports and active living·2026
Same author

Peripheral and central vestibular neuromodulation improve postural control in adolescent idiopathic scoliosis: a randomized, sham-controlled, multi-arm intervention study.

Journal of neuroengineering and rehabilitation·2026
Same author

Integrative multi-omics analysis identifies endocrine-disrupting chemical-related molecular mechanisms in migraine.

The journal of headache and pain·2026
Same author

PancDS in Real-World Practice: A Prospective Multicenter Validation of a Clinical Decision-Support System Bridging Experience Gaps in Pancreatic Lesion Diagnosis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Neuromuscular control mechanism during posture-cognition dual task in mild cognitive impairment: a concurrent fNIRS-sEMG-COP study.

GeroScience·2026
Same author

PPP2R2C confers radioresistance in nasopharyngeal carcinoma by suppressing ferroptosis via RPS27L stabilization.

Cell death & disease·2026

Related Experiment Video

Updated: Jun 9, 2025

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
08:42

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

16.0K

Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study.

Qiong Lyu1,2,3, Rong Chen4, Zhengang Qiu5,6

  • 1Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China.

Scientific Reports
|October 29, 2024
PubMed
Summary
This summary is machine-generated.

New research identifies P2RX7 and RNASET2 as potential therapeutic targets for Parkinson's disease (PD). These genes show altered expression in PD and may offer new avenues for treatment beyond symptom management.

Keywords:
Differential expression analysisMendelian randomizationParkinson’s diseaseSummary statistics-based MRTargeted therapy

More Related Videos

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.5K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.4K

Related Experiment Videos

Last Updated: Jun 9, 2025

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes
08:42

Application of a C. elegans Dopamine Neuron Degeneration Assay for the Validation of Potential Parkinson's Disease Genes

Published on: July 18, 2008

16.0K
Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.5K
Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons
09:21

Author Spotlight: Generating Neuronal Phenotypic Profiles - A Protocol to Culture and Image Human Midbrain Dopaminergic Neurons

Published on: July 7, 2023

1.4K

Area of Science:

  • Neuroscience
  • Genetics
  • Pharmacology

Background:

  • Parkinson's disease (PD) is a common neurodegenerative disorder.
  • Current PD treatments manage symptoms but do not halt disease progression and can cause side effects.
  • Novel druggable therapeutic targets are essential for effective PD intervention.

Purpose of the Study:

  • To identify novel druggable genes associated with Parkinson's disease.
  • To investigate the causal relationship between gene expression and PD using genetic analysis.
  • To explore the potential of identified targets for therapeutic development in PD.

Main Methods:

  • Analysis of six GEO transcriptomic datasets from the substantia nigra region in PD.
  • Mendelian randomization (MR) and summary statistics-based MR (SMR) analyses using brain and blood eQTL data.
  • Validation of candidate gene expression in relation to disease stage using dataset GSE49036.
  • Phenome-wide MR analysis to assess the impact of candidate genes on other complex traits.

Main Results:

  • Identified 313 differentially expressed, potentially targetable genes in PD.
  • P2RX7 and RNASET2 were confirmed as feasible PD therapeutic targets via MR and SMR analyses.
  • Expression of P2RX7 and RNASET2 increased with PD progression (Braak stages).
  • Phenome-wide MR analysis indicated additional effects of targeting RNASET2.

Conclusions:

  • P2RX7 and RNASET2 represent promising druggable targets for Parkinson's disease.
  • Genetic evidence supports the therapeutic potential of targeting these genes.
  • This research provides a foundation for developing new PD therapeutics.