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Updated: Jun 9, 2025

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
Immune therapeutic strategies for the senescent tumor microenvironment
Tadahito Yasuda1, Y Alan Wang2,3
1Brown Center for Immunotherapy, Department of Medicine, Indiana University School of Medicine, Indianapolis, USA. tayasuda@iu.edu.
None:
Senescent cells can either to promote immunosuppressive tumor microenvironment or facilitate immune surveillance. Despite the revolutionary impact of cancer immunotherapy, durable responses in solid tumors, particularly in advanced stages, remain limited. Recent studies have shed light on the influence of senescent status within the tumor microenvironment (TME) on therapy resistance and major efforts are needed to overcome these challenges. This review summarizes recent advancements in targeting cellular senescence, with a particular focus on immunomodulatory approaches on the hallmarks of cellular senescence.
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