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Updated: Jun 9, 2025

High-resolution Imaging of Nuclear Dynamics in Live Cells under Uniaxial Tensile Strain

High-resolution Imaging of Nuclear Dynamics in Live Cells under Uniaxial Tensile Strain

Published on: June 2, 2019

Rupture strength of living cell monolayers.

Julia Duque¹, Alessandra Bonfanti², Jonathan Fouchard^3,4

¹London Centre for Nanotechnology, University College London, London, UK. j.duque@ucl.ac.uk.

Nature Materials

|October 29, 2024

Summary

This summary is machine-generated.

Epithelial monolayers resist large deformations through keratin networks, which increase stiffness. Disrupting this network weakens tissues, highlighting keratin

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Area of Science:

Cell biology
Biophysics
Tissue mechanics

Background:

Epithelial tissues must withstand mechanical stress to function.
Tissue rupture is crucial for development (e.g., blastocoel formation) but poorly understood.
Rupture is a multiscale phenomenon involving molecular, cellular, and mechanical interactions.

Purpose of the Study:

To characterize rupture in epithelial monolayers.
To understand the interplay between mechanical forces and biological processes at multiple scales.

Main Methods:

Mechanical measurements
Live imaging
Computational modeling

Main Results:

Epithelial monolayers can undergo large deformations (several-fold increases in length) before rupture.
At large deformations, epithelia exhibit strain-stiffening, increasing stiffness via supracellular keratin filament networks.
Disruption of the keratin network compromises monolayer integrity and prevents strain-stiffening.

Conclusions:

Supracellular keratin networks are critical for epithelial monolayer mechanical robustness.
Tissue rheology and deformation history influence the strain and stress at rupture onset.
Understanding rupture mechanics is essential for developmental biology and tissue engineering.