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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Related Experiment Video

Updated: Jun 9, 2025

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

Repeatability, Reproducibility, and Observer Variability of Cortical T1 Mapping for Renal Tissue Characterization.

Magdalena Nowak¹, Markus Henningsson¹, Tom Davis¹

¹Perspectum Ltd, Oxford, UK.

Journal of Magnetic Resonance Imaging : JMRI

|October 29, 2024

Summary

This summary is machine-generated.

Kidney cortical T1 mapping is a reliable MRI technique for assessing kidney health. This study confirms its high repeatability and reproducibility across different scanners and observers.

Keywords:

MOLLI T1 kidney repeatability reproducibility

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Last Updated: Jun 9, 2025

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Published on: March 30, 2015

Area of Science:

Medical Imaging
Nephrology
Biomarker Development

Background:

Growing prevalence of kidney diseases necessitates noninvasive imaging biomarkers.
Renal cortical T1 mapping shows potential but requires further technical validation.

Purpose of the Study:

Evaluate repeatability, reproducibility, and observer variability of kidney cortical T1 mapping.
Assess the technique in healthy human volunteers.

Main Methods:

Prospective study involving three cohorts of healthy volunteers.
Utilized modified Look-Locker imaging (MOLLI) with bSSFP readout on 1.5T and 3T MRI scanners.
Statistical analyses included Bland Altman, coefficient of variation (CoV), intra-class coefficient (ICC), and repeatability coefficient (RC).

Main Results:

High repeatability across scanner field strengths and manufacturers (CoV 1.9%-2.8%, ICC 0.79-0.88).
Good reproducibility between scanners (CoV 3.0%, ICC 0.75).
Robust observer variability with minimal impact (CoV 0.6%-1.4%, ICC 0.93-0.98).

Conclusions:

Kidney cortical T1 mapping is a highly repeatable and reproducible MRI method.
The technique demonstrates reliability across different MRI manufacturers, field strengths, and observers.
Supports its use as a noninvasive biomarker for kidney diseases.