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Related Concept Videos

Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

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Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
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Aseptic techniques prevent contamination, ensure experimental accuracy, and protect researchers and microbial cultures. These techniques are essential in clinical, industrial, and research settings where sterility is required.Maintaining Sterility in Laboratory PracticesScientists maintain sterility by sterilizing tools with heat or chemicals, disinfecting work surfaces, and handling cultures in controlled environments. Working near an open flame or within a laminar flow hood reduces the risk...
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Updated: Jun 9, 2025

Probiotic Studies in Neonatal Mice Using Gavage
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Published on: January 27, 2019

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The case for microbial intervention at weaning.

Julia N Flores1,2, Jean-Bernard Lubin1, Michael A Silverman1,2,3,4

  • 1Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Gut Microbes
|October 29, 2024
PubMed
Summary
This summary is machine-generated.

The weaning period significantly alters the gut microbiome and immune system development. This critical window offers a prime opportunity for microbiome-targeted therapies to improve immune health and disease risk.

Keywords:
Microbiomecomplementary feedingimmune system developmentmicrobial ecologyprobioticsweaning

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Area of Science:

  • Microbiology
  • Immunology
  • Nutritional Science

Background:

  • Weaning triggers the most substantial gut microbiome shifts in mammals.
  • This period is crucial for immune system development and establishing long-term immune homeostasis.
  • Altered host-microbe interactions during weaning can influence autoimmune and inflammatory disease risk.

Purpose of the Study:

  • To comprehensively analyze nutritional, microbial, and physiological changes during weaning.
  • To explore species- and region-specific variations in weaning processes.
  • To identify the weaning transition as an optimal window for microbiome-targeted interventions.

Main Methods:

  • Review of existing literature on weaning, gut microbiome, and immunology.
  • Comparative analysis across different species, lifestyles, and intestinal regions.
  • Application of microbial ecology principles to understand host-microbe dynamics.

Main Results:

  • Weaning involves significant changes in diet, gut microbiota, and host physiology.
  • These changes exhibit considerable variation across species and anatomical locations.
  • The weaning transition presents a unique opportunity for therapeutic interventions.

Conclusions:

  • The weaning period is a critical juncture for microbiome development and immune programming.
  • Microbiome-targeted therapies during weaning hold potential for preventing immune-related diseases.
  • Further research into diet-microbe-host interactions can advance microbial therapeutics.