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Updated: Jun 9, 2025

Author Spotlight: Development and Application of a Novel Suture Technique for Annular Fibrosus Repair in Percutaneous Transforaminal Endoscopic Discectomy
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Multifunctional Analgesic Sutures from Microfluidic Spinning Technology.

Yunan Peng1, Yixuan Shang1, Junyi Che1

  • 1Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, China.

Advanced Healthcare Materials
|October 29, 2024
PubMed
Summary
This summary is machine-generated.

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New microfibers offer long-lasting pain relief for surgical sutures. Developed using microfluidic spinning, these analgesic sutures improve wound recovery by encapsulating ropivacaine (ROP) within polycaprolactone (PCL) fibers.

Area of Science:

  • Biomaterials Engineering
  • Drug Delivery Systems
  • Surgical Innovation

Background:

  • Sutures are standard for surgical wound repair, but managing post-operative pain and ensuring timely healing remain challenges.
  • Current methods often involve additional pain management strategies, increasing complexity and patient burden.

Purpose of the Study:

  • To develop novel microfibers for sutures with integrated, long-lasting analgesic properties.
  • To investigate the potential of microfluidic spinning for creating advanced wound closure materials.

Main Methods:

  • Polycaprolactone (PCL) microfibers encapsulating ropivacaine (ROP) were fabricated using a microfluidic spinning technique with solvent extraction.
  • The microfibers' morphology, mechanical properties, and drug release kinetics were characterized.
Keywords:
local anestheticslong‐lasting analgesiamicrofibersmicrofluidicssutures

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  • In vitro and in vivo biocompatibility assessments were performed.
  • The analgesic efficacy was evaluated in a mouse incision pain model.

    • Main Results:

    • Microfluidic spinning enabled controlled fabrication of PCL-ROP microfibers with tailored properties.
    • The microfibers demonstrated good biocompatibility.
    • In vivo studies confirmed a lasting analgesic effect in mice with incision pain.
    • The developed microfibers show potential for direct application as analgesic sutures.

    Conclusions:

    • Microfluidic spinning is a viable method for producing multifunctional analgesic sutures.
    • These PCL-ROP microfibers offer a promising solution for enhanced post-operative pain management and wound healing.
    • This technology could advance the clinical use of fiber-based materials for surgical wound treatment.