STAT3/p-STAT3 expression is correlated with clinicopathological characteristics and prognosis in non-small cell lung cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Signal transducer and activator of transcription factor 3 (STAT3) and its phosphorylated form (p-STAT3) are upregulated in non-small cell lung cancer. p-STAT3 correlates with age and pathology, suggesting its potential as a biomarker.
Area Of Science
- Oncology
- Molecular Biology
- Biomarker Discovery
Background
- Signal transducer and activator of transcription factor 3 (STAT3) is implicated in tumorigenesis.
- Prognostic significance of STAT3/p-STAT3 in non-small cell lung cancer (NSCLC) remains underexplored.
Purpose Of The Study
- To investigate the prognostic value of STAT3 and phosphorylated STAT3 (p-STAT3) in NSCLC.
- To determine the association of STAT3/p-STAT3 expression with clinical characteristics and patient survival.
Main Methods
- Immunohistochemistry was used to assess STAT3/p-STAT3 expression in 239 NSCLC tissues and 71 normal lung tissues.
- Statistical analyses included Pearson's Chi-squared test and Kaplan-Meier survival analysis.
Main Results
- STAT3/p-STAT3 was significantly upregulated in NSCLC tissues compared to normal tissues (p<0.001).
- p-STAT3 expression correlated with patient age (p=0.046) and pathological types (p=0.037).
- STAT3 positivity was associated with poorer survival in patients over 60 (p=0.043) but was not an independent prognostic factor in multivariate analysis (p=0.083).
Conclusions
- STAT3/p-STAT3 is upregulated in NSCLC and may serve as a potential biomarker.
- Further research is warranted to fully elucidate the role of STAT3/p-STAT3 in NSCLC prognosis.
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