Related Experiment Video
Updated: Jun 9, 2025
Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
Published on: December 21, 2019
Asbestos Exposure and Malignant Pleural Mesothelioma: A Systematic Review of Literature
Cátia Santos1, Maria Dos Anjos Dixe2, Ema Sacadura-Leite3
1NOVA National School of Public Health, Universidade NOVA de Lisboa, Center for Innovative Care and Health Technology (ciTechCare), Polytechnic of Leiria, Leiria, Portugal.
Background:
The relationship between exposure to asbestos and malignant pleural mesothelioma (MPM) is already well established. Nevertheless, much remains to be known about exposure thereto and the incidence and mortality from MPM.
Objective:
This systematic review aims to map the relationship between asbestos and MPM by studying the exposure to asbestos and the incidence and mortality of MPM.
Methods:
A systematic review was conducted relating asbestos and MPM. Exposure to asbestos, incidence, and mortality by MPM was reviewed. PubMed, Web of Science, Cochrane Library, RCAAP, DART-Europe, and the reference lists of included studies were searched, from January 1, 1960, to December 31, 2020. Methodological quality was checked, the risk of bias analysis was performed, a level of evidence grade was assigned, and descriptive data analysis was performed.
Results:
3,484 unique citations were identified, which included seventeen observational studies that met inclusion criteria with a total of 1,104 patients. Heterogeneity is present between the included studies which range from a case series of 16 retrospective studies and 1 prospective study. Studies were mostly conducted in Europe, particularly in Italy (6), and were published between 1969 and 2020. The mean age of patients is approximately 66 years with a latency period between the first exposure and diagnosis of approximately 42 years. 14 studies present data regarding the occupational context and chrysotile and crocidolite are the most studied types of fibre. The incidence of cases occurred between the interval 1966 and 2014 and in 9 studies the mortality rate was 100% of patients.
Conclusion:
There is high evidence to support the relationships between asbestos and MPM. However, the relatively scant information provided by the studies reinforces the need for well-conducted research and implementation of National Mesothelioma Surveillance Centres at a global level.
Insights
Asbestos exposure is strongly linked to malignant pleural mesothelioma (MPM). This review highlights the need for global mesothelioma surveillance centers due to limited data on asbestos exposure and MPM incidence/mortality.
Area of Science:
- Environmental Health
- Occupational Medicine
- Oncology
Background:
- The link between asbestos exposure and malignant pleural mesothelioma (MPM) is established.
- However, detailed information on asbestos exposure levels and their correlation with MPM incidence and mortality remains limited.
Purpose of the Study:
- To systematically review the existing literature on asbestos exposure and its relationship with the incidence and mortality of malignant pleural mesothelioma (MPM).
Main Methods:
- A systematic review of studies published between 1960 and 2020 was conducted.
- Searches included major databases (PubMed, Web of Science, Cochrane) and reference lists.
- Methodological quality, risk of bias, and evidence levels were assessed, followed by descriptive data analysis.
Main Results:
- Seventeen observational studies with 1,104 patients were included, primarily from Europe (Italy).
- The average patient age was 66 years, with a median latency of 42 years post-exposure.
- Occupational asbestos exposure was common, with chrysotile and crocidolite being frequently studied fibers; mortality rates reached 100% in some studies.
Conclusions:
- High-level evidence confirms the association between asbestos and MPM.
- The scarcity of comprehensive data underscores the necessity for improved research and global implementation of National Mesothelioma Surveillance Centres.
Related Concept Videos
01:30Pleural Disorders: Types and Brief Description
01:28Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
01:13Pleura of the Lungs
01:30Criteria for Causality: Bradford Hill Criteria - I
01:25Pleural Effusion I: Introduction
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...