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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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The role of p53 in male infertility

Jing Li1, Xia Huang2, Lei Luo3

  • 1Department of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, China.

Frontiers in Endocrinology
|October 29, 2024
PubMed

Insights

The tumor suppressor p53 is crucial for male reproductive health, impacting sperm cell development and DNA repair. Targeting p53 offers potential new treatments for male infertility.

Area of Science:

  • Reproductive Biology
  • Molecular Biology
  • Genetics

Background:

  • The tumor suppressor p53 is a key transcription factor regulating cell cycle arrest, DNA repair, and apoptosis.
  • Emerging evidence highlights p53's significant roles in spermatogenesis and male infertility.

Purpose of the Study:

  • To review the multifaceted roles of p53 in spermatogenesis.
  • To analyze p53's involvement in the development of male infertility.
  • To explore potential therapeutic strategies targeting p53 for male infertility.

Main Methods:

  • Literature review of studies on p53 function in male reproduction.
  • Analysis of p53's mechanisms in spermatogonial stem cell proliferation, differentiation, apoptosis, and DNA repair.
  • Examination of p53's association with male infertility-related diseases.

Main Results:

  • p53 influences spermatogonial stem cell proliferation and differentiation.
  • p53 regulates spontaneous apoptosis and DNA damage repair during spermatogenesis.
  • Dysregulation of p53 is linked to various forms of male infertility.

Conclusions:

  • p53 plays critical roles throughout spermatogenesis.
  • Understanding p53's mechanisms in male infertility can inform novel therapeutic approaches.
  • Targeting p53 presents a promising avenue for male infertility treatment.
Keywords:
drug targetmale infertilityp53spermatogenesisstrategy

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