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Updated: Jun 9, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
Published on: October 28, 2020
Three-Dimensional Speckle Tracking Echocardiography Assessment of Right Ventricular Function in Chronic Coronary
WenShu Hu1, Chang Zhou1, Heng Sun1
1Department of Ultrasound, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Insights
Percutaneous coronary intervention (PCI) improves right ventricular (RV) function in chronic coronary syndrome patients within six months. However, RV free wall longitudinal strain (RVFWLS) remains lower than controls at 12 months post-PCI.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Function Assessment
Background:
- Chronic coronary syndromes can impact cardiac function.
- Percutaneous coronary intervention (PCI) is a common treatment for coronary artery disease.
- Assessing right ventricular (RV) function post-PCI is crucial for patient outcomes.
Purpose of the Study:
- To evaluate changes in RV systolic function after PCI in patients with chronic coronary syndromes.
- To compare RV function metrics between patients and healthy controls.
- To assess the utility of three-dimensional speckle tracking echocardiography (3D-STE) in monitoring RV function post-PCI.
Main Methods:
- A prospective study included 136 patients undergoing PCI for chronic coronary syndromes and 110 healthy controls.
- Echocardiography, including conventional and 3D-STE, was performed at 1 week, 6 months, and 12 months post-PCI.
- Key parameters measured included TAPSE, S', RVFAC, RVFWLS, RVGLS, RVSV, and RVEF.
Main Results:
- Significant improvements in RV function parameters (TAPSE, S', RVFAC, RVGLS, RVSV, RVEF) were observed from 1 week to 6 months post-PCI.
- While some parameters showed no significant change between 6 and 12 months, TAPSE, S', and RVFWLS continued to increase significantly.
- At 12 months, RVFWLS remained significantly lower in patients compared to healthy controls, despite other RV function metrics showing no significant difference.
Conclusions:
- Right ventricular systolic function significantly improves after PCI in chronic coronary syndrome patients.
- RVFWLS remains a potential indicator of persistent RV dysfunction post-PCI.
- 3D-STE is a valuable noninvasive tool for quantifying RV systolic function in this patient population.
Objective:
This study aimed to assess alterations in right ventricular (RV) function following percutaneous coronary intervention (PCI) in patients with chronic coronary syndromes utilizing three-dimensional speckle tracking echocardiography (3D-STE).
Methods:
A prospective study was conducted involving 136 patients diagnosed with chronic coronary syndromes undergoing PCI, constituting the study group, alongside 110 age- and gender-matched healthy volunteers serving as the control group. Echocardiographic evaluations, including both conventional and three-dimensional assessments, were performed on all study participants at 1-week, 6, and 12 months post-PCI. Parameters such as tricuspid annular plane systolic excursion (TAPSE) were derived from conventional echocardiography, while tricuspid lateral annular systolic velocity (S') was measured via tissue Doppler imaging. 3D-STE was utilized to quantify metrics including right ventricular fractional area change (RVFAC), right ventricular free wall longitudinal strain (RVFWLS), right ventricular global longitudinal strain (RVGLS), right ventricular stroke volume (RVSV), and right ventricular ejection fraction (RVEF).
Results:
TAPSE, S', RVFAC, RVFWLS, RVGLS, RVSV, and RVEF exhibited significant increases from 1-week to 6 months post-PCI (p < 0.05). However, from 6 to 12 months post-PCI, RVFAC, RVGLS, RVSV, and RVEF demonstrated no notable changes (p > 0.05). Meanwhile, TAPSE, S', and RVFWLS sustained significant elevations: TAPSE (19.63 ± 3.253% to 22.603 ± 2.885%, p < 0.001); S' (10.57 ± 2.643 to 12.61 ± 2.189 cm/s, p < 0.001); RVFWLS (18.64 ± 2.745% to 19.926 ± 3.291%, p = 0.002). At 12 months post-PCI, S', RVFAC, RVGLS, RVSV, and RVEF remained lower than those of the healthy control group, but the differences were not statistically significant (p > 0.05). However, RVFWLS was significantly lower compared to the healthy control group (19.926 ± 3.291% vs. 22.10 ± 1.994%, p < 0.001).
Conclusion:
Following PCI, right ventricular systolic function in patients with chronic coronary syndromes improves significantly over time. However, even at the 12-month post-PCI mark, RVFWLS remains lower than that of the control group. Notably, 3D-STE emerges as a noninvasive method for quantifying right ventricular systolic function post-PCI in chronic coronary syndrome patients.
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