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Fiber Reinforced Concrete01:22

Fiber Reinforced Concrete

Fiber-reinforced concrete significantly enhances the structural and nonstructural properties of traditional concrete by incorporating fibers like steel, glass, and polymers. These fibers, varying from natural ones such as sisal and cellulose to manufactured ones like polypropylene and Kevlar, are mixed into hydraulic cement with aggregates. Steel fibers, often preferred for their robustness, contribute to improved ductility, toughness, and post-cracking performance. The concrete is classified...

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Related Experiment Video

Updated: Jun 25, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
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Carboxymethyl cellulose-stabilized calcium phosphate particles for injectable hydrogel-based bone tissue engineering.

Piyaporn Srisura1, Yuwaporn Pinyakit1, Umphan Ngoensawat1

  • 1Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Pathumwan, Bangkok, 10330, Thailand. vipavee.p@chula.ac.th.

Soft Matter
|October 29, 2024
PubMed
Summary

Researchers stabilized amorphous calcium phosphate (CaP) particles using carboxymethyl cellulose (CMC) to improve their stability for bone regeneration. The stabilized CaP/CMC particles were incorporated into an injectable methacrylated hyaluronic acid (MeHA) hydrogel for enhanced bone repair applications.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Calcium phosphate (CaP) is a key biomaterial in bone tissue engineering due to its osteoconductive properties.
  • Amorphous calcium phosphate (aCaP) offers high reactivity for bone regeneration but suffers from poor stability in aqueous environments.
  • Instability of aCaP limits its clinical application in bone defect treatments.

Purpose of the Study:

  • To enhance the stability and injectability of amorphous calcium phosphate particles.
  • To investigate the use of carboxymethyl cellulose (CMC) as a stabilizer for amorphous calcium phosphate.
  • To develop a composite injectable hydrogel for bone regeneration applications.

Main Methods:

  • An in situ wet chemical method was employed to synthesize CaP/CMC composite particles.
  • Carboxymethyl cellulose (CMC) was used at a concentration of 500 mg L-1 to stabilize CaP particles.
  • Synthesized CaP/CMC particles were incorporated into a methacrylated hyaluronic acid (MeHA) hydrogel matrix.

Main Results:

  • Carboxymethyl cellulose effectively stabilized amorphous calcium phosphate particles, preventing phase transformation.
  • The addition of CMC improved the dispersity of CaP particles in aqueous solutions.
  • The resulting CaP/CMC-loaded MeHA hydrogel demonstrated potential as a stable, injectable bone regeneration material.

Conclusions:

  • Carboxymethyl cellulose serves as an effective stabilizer for amorphous calcium phosphate particles.
  • The developed injectable MeHA hydrogel incorporating stabilized CaP/CMC particles shows promise for bone tissue engineering.
  • This approach offers a viable strategy for creating stable and injectable biomaterials for enhanced bone regeneration.