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Related Experiment Videos

Constitutional hypofibrinogenemia associated with third trimester hemorrhage.

D K McRoyan, C J McRoyan, D Z Kitay

    Annals of Clinical and Laboratory Science
    |January 1, 1986
    PubMed
    Summary

    Constitutional hypofibrinogenemia, a bleeding disorder, may be linked to third-trimester hemorrhage in pregnancy. Low fibrinogen levels can disrupt the uteroplacental interface, leading to complications.

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    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Reproductive Medicine

    Background:

    • Constitutional hypofibrinogenemia is a rare bleeding disorder characterized by low levels of fibrinogen.
    • Pregnancy can unmask or exacerbate pre-existing hemostatic disorders.
    • Third-trimester hemorrhage is a significant obstetric complication with potential risks for mother and fetus.

    Observation:

    • A 31-year-old pregnant woman at 32 weeks gestation presented with vaginal bleeding.
    • Persistent low fibrinogen levels (102-155 mg/dL) were observed during the third trimester and postpartum.
    • The patient had no prior significant bleeding history.

    Findings:

    • The case suggests a potential association between constitutional hypofibrinogenemia and third-trimester hemorrhage.

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  • Review of literature revealed a higher incidence of placental abruption, postpartum hemorrhage, and spontaneous abortion in pregnancies of hypofibrinogenemic patients.
  • Low functional fibrinogen levels were implicated in disrupting the uteroplacental interface integrity.

    • Implications:

    • Early identification and management of hypofibrinogenemia in pregnancy are crucial.
    • This condition may require specialized obstetric and hematologic care to mitigate risks.
    • Further research is warranted to understand the pathophysiology and optimize management strategies for pregnant individuals with hypofibrinogenemia.