Related Experiment Video

Updated: Jun 9, 2025

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

3.3K

Prognostic and therapeutic implications of a low aortic valve calcium score in patients with low-gradient aortic

D Juhász1, M Vecsey-Nagy1,2, Á L Jermendy1

  • 1Heart and Vascular Centre, Semmelweis University, 68. Varosmajor u, 1122-Budapest, Hungary.

European Heart Journal. Cardiovascular Imaging
|October 29, 2024
PubMed

Insights

In low-gradient aortic stenosis (LGAS), aortic valve calcium score (AVCS) does not predict prognosis. However, aortic valve intervention (AVI) significantly improves survival in symptomatic LGAS patients with low AVCS.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Interventional Cardiology

Background:

  • Low-gradient (LG) aortic stenosis (AS) presents diagnostic challenges.
  • Aortic valve calcium score (AVCS) is used when echocardiography is discordant.
  • The prognostic value of AVCS in LGAS requires further investigation.

Purpose of the Study:

  • To determine the prognostic significance of AVCS in LGAS.
  • To assess if symptomatic LGAS patients with low AVCS benefit from aortic valve intervention (AVI).

Main Methods:

  • 327 symptomatic severe AS patients (for TAVI planning) were analyzed.
  • AVCS was measured; low AVCS defined by sex-specific thresholds.
  • Patients were categorized into high-gradient (HG) AS and LGAS groups.
  • Outcomes were assessed over a median follow-up of 4.9 years.
  • Propensity score matching compared AVI versus medical treatment.

Main Results:

  • Low AVCS was more prevalent in LGAS (40%) than HGAS (10%).
  • AVCS predicted mortality in HGAS but not in LGAS.
  • In LGAS patients with low AVCS, AVI (94% TAVI) significantly improved survival compared to medical treatment (aHR: 0.102).

Conclusions:

  • Low AVCS is common in LGAS and does not indicate a better prognosis.
  • Symptomatic LGAS patients with low AVCS benefit from AVI.
  • AVI offers similar survival benefits in LGAS patients regardless of AVCS level, comparable to HGAS patients.
Abstract

Keywords:
TAVI (transcatheter aortic valve implantation) aortic valve calcium scorelow-gradient aortic stenosis

More Related Videos

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro05:47

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

Published on: May 10, 2021

3.9K
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots12:17

Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots

Published on: May 21, 2017

11.3K

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
3
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
3
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
12
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
2
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular...
3