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Updated: Jun 9, 2025
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
A bibliometric analysis of bladder cancer and microRNA research: Trends and advances from 2008 to 2022
Wei Zhang1, Gaowei Guo, Xinji Li
1Department of Urology, Jieyang People's Hospital, Jieyang, Guangdong, P. R. China.
Abstract:
Bladder cancer (BC) is a significant global health issue with high incidence and mortality rates. MicroRNAs (miRNAs) play a crucial role in regulating gene expression and have been found to be dysregulated in BC. Understanding the role of miRNAs in BC development could lead to targeted therapies and improved patient management. Our study presents a thorough examination of the correlation between BC and miRNA research from 2008 to 2022. With the help of 3 powerful methods, including VOSviewer, Biblioshiny, and CiteSpace software, we analyzed the retrieved documents from "Core Collection databases online" on the Web of Science. In total, 798 articles were extracted from the Web of Science, and the number of published papers showed an upward trend from 2008 to 2019. The total number of citations was 21,233, of which the highest paper was a review article written by Chan Jiajia et al in 2018 with 752 citations. Based on the result of the coauthor analysis, Seki Naohiko was the most productive writer and China had the highest volume of published articles. Co-citation analysis was used to reveal the knowledge structure of the research field. In addition to the keywords "Bladder cancer" and "miRNA," "Proliferation," "Biomarkers," and "Apoptosis" were the high-frequency used keywords. Recently, increasingly researchers have paid more attention to the field about BC and miRNA around the worldwide. Through in-depth communication and close collaboration, the veil of miRNA in BC has gradually been unveiled. Bibliometric analysis helps to identify hotspots in research and areas for future investigation.
Insights
This bibliometric analysis reveals a growing research trend in bladder cancer (BC) and microRNA (miRNA) studies. Key research areas include proliferation, biomarkers, and apoptosis, highlighting potential therapeutic targets.
Area of Science:
- Oncology
- Molecular Biology
- Bioinformatics
Background:
- Bladder cancer (BC) presents a significant global health challenge with high incidence and mortality.
- MicroRNAs (miRNAs) are critical regulators of gene expression, frequently dysregulated in BC.
- Understanding miRNA roles in BC is vital for developing targeted therapies and improving patient outcomes.
Purpose of the Study:
- To conduct a comprehensive bibliometric analysis of research on bladder cancer and microRNAs.
- To examine the correlation between BC and miRNA research from 2008 to 2022.
- To identify research hotspots, trends, and knowledge structures in this field.
Main Methods:
- Bibliometric analysis of 798 articles from Web of Science Core Collection (2008-2022).
- Utilized VOSviewer, Biblioshiny, and CiteSpace software for data analysis.
- Co-citation analysis and keyword analysis were employed to map the research landscape.
Main Results:
- A notable upward trend in publications from 2008 to 2019, with 21,233 total citations.
- Seki Naohiko identified as the most productive author; China led in article volume.
- High-frequency keywords included 'Proliferation,' 'Biomarkers,' and 'Apoptosis,' alongside 'Bladder cancer' and 'miRNA.'
Conclusions:
- Research on bladder cancer and microRNAs is rapidly expanding globally.
- Bibliometric analysis effectively identifies key research areas and collaboration patterns.
- Further investigation into miRNA's role in BC, focusing on proliferation and apoptosis, is warranted for therapeutic advancements.
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