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Updated: May 7, 2026
Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
Published on: March 8, 2019
A bibliometric and visualization analysis of global trends and frontiers on macrophages in abdominal aortic aneurysms
Liang Zhang1, Dongyu Li2, Shiyang Bao2
1Department of Breast Surgery, Hubei Provincial Clinical Research Center for Breast Cancer, Wuhan Clinical Research Center for Breast Cancer, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Background:
Macrophages are key regulators of the inflammatory and innate immune responses. Researchers have shown that aberrant expression of macrophages contributes to the development of abdominal aortic aneurysms (AAA). However, a comprehensive bibliometric analysis exploring the research status and knowledge mapping of this area is lacking. This study aimed to explore the research status, knowledge mapping and hotspots of macrophages in AAA research from a bibliometric perspective.
Methods:
In this study, we retrieved articles published between 2000 and 2022 on macrophages associated with AAA research from the Web of Science Core Collection (WoSCC) database. The retrieved literature data were further analyzed using Citespace and VOSviewer software.
Results:
A total of 918 qualified publications related to AAA-associated macrophages were retrieved. The number of publications in this field has been increasing annually. China and the United States were the 2 main drivers in this field, contributing to more than 64% of the publications. In addition, the US had the most publications, top institutions, and expert researchers, dominating in research on macrophages in AAA. The Harvard University was the most productive institution, with 60 publications. The journal with the most publications was Arteriosclerosis, Thrombosis, and Vascular Biology (86). Daugherty Alan was the most prolific author (28 publications) and he was also the most cited co- author. Furthermore, the exploration of established animal models, macrophage-related inflammatory-microenvironment, macrophage-related immune mechanism, clinical translation and molecular imaging research remained future research directions in this field.
Conclusions:
Our findings offered new insights for scholars in this field. They will help researchers explore new directions for their work.
Insights
This bibliometric analysis reveals a growing research landscape on macrophages in abdominal aortic aneurysms (AAA). The United States and China lead, with future directions focusing on animal models and clinical translation.
Area of Science:
- Immunology
- Cardiovascular Research
- Bibliometrics
Background:
- Macrophages are critical regulators of inflammatory and innate immune responses.
- Aberrant macrophage expression is linked to abdominal aortic aneurysm (AAA) development.
- A comprehensive bibliometric analysis of this research area is currently lacking.
Purpose of the Study:
- To conduct a bibliometric analysis of research on macrophages in abdominal aortic aneurysms (AAA).
- To map the knowledge landscape and identify research hotspots in this field.
Main Methods:
- Retrieved 918 publications from the Web of Science Core Collection (2000-2022).
- Analyzed literature data using CiteSpace and VOSviewer software.
Main Results:
- Annual publication output shows an increasing trend.
- China and the United States are the leading contributors, accounting for over 64% of publications.
- The United States leads in publications, institutions, and researchers; Harvard University is the most productive institution; Arteriosclerosis, Thrombosis, and Vascular Biology published the most articles; Daugherty Alan is the most prolific and cited author.
Conclusions:
- This study provides valuable insights into the research status and trends of macrophages in AAA.
- Identified future research directions include animal models, inflammatory microenvironments, immune mechanisms, clinical translation, and molecular imaging.
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