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This study used Mendelian randomization to link gut microbiota and functional dyspepsia (FD). Certain gut bacteria were found to be associated with an increased or decreased risk of developing FD.

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Area of Science:

  • Gastroenterology
  • Microbiome Research
  • Genetics

Background:

  • Functional dyspepsia (FD) is a common gastrointestinal disorder with complex etiology.
  • The role of gut microbiota in FD pathogenesis is increasingly recognized but not fully elucidated.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota and functional dyspepsia (FD) using a two-sample Mendelian randomization (MR) approach.
  • To identify specific gut microbial taxa associated with FD risk.

Main Methods:

  • Utilized genome-wide association studies (GWAS) data for gut microbiota (n=18,340) and FD (n=189,695 controls, 4376 cases).
  • Employed inverse variance weighted (IVW) analysis as the primary method for MR analysis.
  • Conducted sensitivity analyses to assess pleiotropy and heterogeneity, ensuring result reliability.

Main Results:

  • Identified seven gut microbial taxa significantly associated with FD.
  • Positive associations with FD were observed for Order/Family Erysipelotrichales, Genus Haemophilus, Genus Ruminiclostridium 9, and Genus Lachnospiraceae NK4A 136 group.
  • Inverse associations with FD were found for Class Gammaproteobacteria and Genus Erysipelatoclostridium.

Conclusions:

  • This MR study provides genetic evidence supporting a link between specific gut microbiota and functional dyspepsia.
  • Findings suggest that alterations in gut microbial composition may contribute to FD development.
  • Further research is warranted to explore the mechanisms underlying the gut microbiota-FD relationship.