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Histone Deacetylases in Metabolism: the Known and the Unexplored
Somaya Y Ibrahim1,2, Jayden Carter2, Rushita A Bagchi2,3
1College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States.
Abstract:
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from key lysine residues on histone and nonhistone proteins and thereby regulate gene transcription. They have been implicated in several biological processes in both healthy and pathological settings. This review discusses the role of HDACs in multiple metabolically active tissues and highlights their contribution to the pathogenesis of tissue-specific maladaptation and diseases. We also summarize the current knowledge gaps and potential ways to address them in future studies.
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