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Prognostic implications and diagnostic significance of TFE3 rearrangement in renal cell carcinoma

  • 0University of Navarra Clinic, Urology, Pamplona, Spain. cmunozbasti@unav.es.
World Journal of Urology +

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October 29, 2024

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October 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

TFE3 rearrangement in renal cell carcinoma (RCC) is linked to higher recurrence and shorter progression-free survival (PFS). Fluorescence in situ hybridization (FISH) is crucial for accurate diagnosis, as immunohistochemistry (IHC) has low specificity.

Area Of Science

  • Oncology
  • Molecular Pathology
  • Genitourinary Pathology

Background

  • Renal cell carcinoma (RCC) encompasses diverse subtypes with varying prognoses.
  • TFE3 rearrangements are found in a subset of RCCs, but their clinical impact requires further elucidation.
  • Immunohistochemistry (IHC) is often used for initial screening, but its diagnostic accuracy for TFE3 rearrangement needs validation.

Purpose Of The Study

  • To investigate the prognostic significance of TFE3 rearrangement in renal cell carcinoma (RCC).
  • To analyze clinicopathological features associated with RCC recurrence in TFE3-rearranged tumors.
  • To evaluate the diagnostic utility of immunohistochemistry (IHC) for TFE3 rearrangement and its correlation with outcomes.

Main Methods

  • Screening of clear cell RCC (ccRCC) patients.
  • Immunohistochemistry (IHC) for TFE3 expression.
  • Fluorescence in situ hybridization (FISH) to confirm TFE3 rearrangement in IHC-positive cases.
  • Collection and analysis of clinicopathological and survival data.

Main Results

  • TFE3 rearrangement was confirmed in 1.15% of RCC cases via FISH.
  • TFE3-rearranged RCC patients were younger and exhibited a significantly higher recurrence rate (50%) compared to ccRCC (18.8%).
  • TFE3 rearrangement, tumor size, and metastasis were independent prognostic factors for recurrence; PFS was significantly shorter in TFE3-rearranged RCC.

Conclusions

  • TFE3 rearrangement is an independent prognostic factor for RCC recurrence and worse progression-free survival (PFS).
  • Fluorescence in situ hybridization (FISH) is essential for confirming TFE3 rearrangement due to the low specificity of IHC.
  • Close follow-up is recommended for patients with TFE3-rearranged RCC.

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