CXCL8 may serve as a potential biomarker for predicting the prognosis and immune response in cervical cancer

Yi Yin ¹, Yong Li ¹, Yaoyang Zhang ²

⁰Department of Gynecology, Tumor Hospital Affiliated to Nantong University, Nantong, 226006, Jiangsu, China.

Discover Oncology +

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October 29, 2024

View abstract on PubMed

Summary

Chemokine CXCL8 (CXCL8) impacts tumor prognosis and immune response in various cancers, especially cervical cancer. Elevated CXCL8 levels correlate with poorer survival and altered immune cell infiltration, suggesting its potential as a prognostic biomarker.

Area Of Science

Oncology
Immunology
Bioinformatics

Background

The chemokine CXCL8 (CXCL8) is implicated in various biological processes.
Understanding CXCL8's role in cancer prognosis and immune modulation is crucial.

Purpose Of The Study

To investigate the prognostic significance of CXCL8 in cervical cancer.
To analyze CXCL8's effect on the tumor immune microenvironment using bioinformatics.

Main Methods

Utilized HPA, TIMER2.0, and TCGA databases for gene expression and survival analysis.
Correlated CXCL8 expression with overall survival (OS), progression-free interval (PFI), and immune checkpoint genes.
Assessed CXCL8's association with tumor-infiltrating immune cells (TIICs) and performed enrichment analysis.

Main Results

CXCL8 expression is elevated in most tumor tissues compared to normal tissues.
CXCL8 levels significantly correlate with OS and PFI across various cancers.
CXCL8 is associated with immune checkpoint gene expression, TIIC infiltration, and immune-related pathways in cervical cancer.

Conclusions

CXCL8 influences tumor prognosis by modulating immune infiltration, particularly in cervical cancer.
CXCL8 shows potential as a prognostic and immunomodulatory biomarker for cancer patients.

Keywords:

Bioinformatics CXCL8 Immune infiltration