Related Experiment Video
Updated: Jun 9, 2025
08:25
Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate
Published on: April 6, 2022
1.8K
Rapid virus inactivation by nanoparticles-embedded photodynamic surfaces
Gengxin Zhang1, Jiewen Zhou2, Quanjie Lv1
1State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Journal of Colloid and Interface Science
|October 29, 2024
Summary
New antiviral surfaces rapidly inactivate viruses using photodynamic nanoparticles. These surfaces generate reactive oxygen species (ROS) to effectively combat both enveloped and non-enveloped viruses, offering a promising solution for epidemic control.
Area of Science:
- Materials Science
- Nanotechnology
- Virology
Background:
- Viral epidemics pose significant health risks, necessitating effective antiviral strategies.
- A lack of accessible antiviral coatings limits current mitigation efforts.
- Antiviral surfaces are crucial for controlling transmission via bioaerosols and surface contamination.
Purpose of the Study:
- To develop and evaluate photodynamic nanoparticle-embedded surfaces for rapid viral inactivation.
- To address the scarcity of effective antiviral coatings for epidemic control.
Main Methods:
- Core-shell methylene blue (MB)-loaded SiO2 nanoparticles were synthesized with high reactive oxygen species (ROS) yield.
- Nanoparticles were immobilized onto air filter fibers, maintaining ROS production.
- Enveloped and non-enveloped viruses were exposed to the modified surfaces under specific light conditions.
Main Results:
- The nanoparticle-embedded surfaces demonstrated rapid inactivation of three different viruses (>6 log units within 12 min).
- High ROS yield was sustained on the air filter fibers, preventing aggregation-caused quenching.
- Photodynamic inactivation primarily targeted viral envelope glycoproteins.
Conclusions:
- Photodynamic nanoparticle-embedded surfaces provide a swift and effective method for viral inactivation.
- This strategy offers a versatile approach to combatting viral transmission during epidemics.
- The developed surfaces show potential for use in air filtration and other applications requiring viral decontamination.
