Source and bioavailability of quaternary ammonium compounds (QACs) in dust: Implications for Nationwide Exposure in...

Quaternary ammonium compounds (QACs), widely used in various disinfectants products during the COVID-19 Pandemic, raised the concerns on their exposure and health effect. To date, the sources of QACs in indoor environments have been largely ignored. Additionally, there is no information on the nationwide human exposure assessment of QACs in China after the COVID-19. Herein, analysis of QACs in household products, including personal care (n = 27), cleaning (n = 6) and disinfection products (n = 11) from different manufacturing companies further confirmed there are extensive application of QACs in household products, raising their potential exposure to humans. QACs were frequently detected in indoor dust samples (n = 370) from 111 cities of 31 provinces/municipalities across China, with median concentration of 6778 ng/g. Benzalkyldimethylammonium compounds (BACs) and alkyltrimethylammonium compounds (ATMACs) were identified as the dominant QACs in dust samples, with the proportions of 44 % and 46 %, respectively. The in vivo bioavailability experiment (C57BL/6 male mice) showed that the relative bioavailability (RBA) of QACs through dust ingestion ranged from 5.08 % to 66.3 % and 60.3 % to 118 % in the low and high-dose group, respectively. Compared to the pre-adjustment scenario of RBA values, the exposure risk of QACs was overestimated by 2.23 - 5.14 times.