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Strontium doped 58S bioglass incorporated chitosan/gelatin porous scaffold for bone tissue engineering applications

  • 0Center of Excellence in Tissue Engineering, Department of Biotechnology and Medical Engineering, National Institute of Technology, Rourkela, Odisha 769008, India; Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand 247667, India.
International Journal of Biological Macromolecules +

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October 29, 2024

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October 29, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Strontium-doped bioglass nanoparticles incorporated into chitosan/gelatin scaffolds enhance bone regeneration. These novel scaffolds exhibit improved mechanical strength and promote cell proliferation and osteogenic differentiation for tissue engineering.

Area Of Science

  • Biomaterials Science
  • Tissue Engineering
  • Nanotechnology

Background

  • Bioglass (Bg) is a revolutionary material for bone regeneration.
  • Strontium (Sr) doping in bioglass enhances bioactivity and inhibits osteoclast formation.
  • Chitosan (CS) and gelatin (GE) are biocompatible polymers suitable for scaffolds.

Purpose Of The Study

  • To develop chitosan/gelatin porous scaffolds incorporating strontium-doped bioglass nanoparticles (nSrBg).
  • To evaluate the potential of these scaffolds for bone tissue engineering applications.

Main Methods

  • Fabrication of CS/GE scaffolds with nSrBg nanoparticles.
  • Scanning Electron Microscopy (SEM) for microstructure analysis.
  • Swelling, degradation, compression, in vitro bioactivity, MTT, and ALP assays.

Main Results

  • Scaffolds exhibited a homogenous microstructure with 100-300 μm interconnected pores.
  • Achieved <6-fold swelling and <50% degradation rate.
  • nSrBg incorporation improved mechanical strength to 1.15 MPa.
  • Enhanced apatite layer deposition, cell attachment, proliferation (0.48 OD), and osteogenic potential (0.70 OD).

Conclusions

  • The fabricated nSrBg-incorporated CS/GE scaffolds possess superior mechanical and biological properties.
  • These scaffolds show significant promise as a platform for bone tissue regeneration.

Keywords: